Clark was born November 15, 1954 in Detroit, Michigan, and her mother, Dr. Mattie Moss Clark, a gospel music innovator in her own right, introduced her to piano as an infant, and by the age of four, Clark was playing full songs on the instrument. By the time she was nine, Clark had switched to the organ, and by 12, she had made her recording debut as an organist on the Southwest Michigan State Choir's album A Closer Walk with Thee. She was to remain her mother's organist until Dr. Clark's death in 1994.

Clark wrote and produced a couple of albums for her mother, but her best-known compositions and productions were for her sibling gospel group the Clark Sisters, the legendary sibling gospel ensemble that also included sisters Karen, Dorinda, and Jacky Clark. With her formal music training (she studied classical music at Howard University in Washington, D.C.) and her love for jazz, reggae, and R&B (and later even hip-hop, disco, and ragtime), Clark's arrangements and productions were an innovative blend that literally kicked gospel into the modern era. She had begun writing songs in her teens in the 1970s, and based on her exciting, vocal-based organ runs and trills, they had depth and substance, and in many ways she functioned in the Clark Sisters the way Brian Wilson did with the Beach Boys, using the group to make large sonic statements.

The Clark Sisters were able to cross over to the secular charts and fill dancefloors everywhere with 1981's "You Brought the Sunshine," and gospel had never really sounded like this before. Some of it had to do with Clark's organ playing, which was singular and always striking, earning her the title of Queen of the Hammond B-3 in gospel circles and beyond. She left the Clark Sisters officially in 1989 to devote more time to her own ministry, although she continued to add her production, songwriting, and organ expertise to various projects, and continued to surface from time to time with solo albums, including Praise Belongs to God (1979), Ye Shall Receive Power (1981), Comin' Home (1982), Masterpiece (1996), Live in Charlotte (2002), and Home Once Again: Live in Detroit (2004). A national treasure if there ever were one, Clark continued to be a presence a decade and change into the 21st century, releasing With Humility in 2011 and Live & Unplugged in 2013. ~ Steve Leggett