After Discount ended in 2000, VV began exchanging tapes with the London-based Hotel through the mail, but both of them felt hindered by this method, so VV crossed the Atlantic so the duo could write faster. In spring of 2001, they issued a self-released demo that showcased their gritty, sexy sound and earned favorable reviews from such quarters as TapeOp Magazine. They also contributed a song, "Restaurant Blouse," to 5 Rue Christine's If the Twenty-First Century Did Not Exist It Would Be Necessary to Invent It compilation early in 2002, before their debut EP, Black Rooster, arrived that summer on Dim Mak.

Along with gigs at the London and Glasgow LadyFests and tour dates alongside Le Tigre, the Kills also toured the U.S. for eight weeks before returning to London to finish their first full-length album, Keep on Your Mean Side, which was released by Rough Trade in spring 2003. A second album, No Wow, arrived in 2005 and was an even dirtier, leaner collection of songs. The Kills retooled their sound for 2008's Midnight Boom, mixing more electronic beats and pop hooks into their punky bedrock.

While touring alongside the Raconteurs in support of Midnight Boom, Mosshart struck up a friendship with frontman Jack White, prompting the two to form a supergroup, the Dead Weather, in 2009. The Kills took a short break while the Dead Weather worked feverishly, issuing two albums in ten months and touring behind both. Blood Pressures ended the hiatus in 2011. The following year, the band released Dream & Drive, a collection of photographs taken by close friend and collaborator Kenneth Cappello, who also directed several of their videos. During the next few years, Mosshart moved to Nashville to pursue her visual art career as well as continue her work with the Dead Weather, while Hince suffered an injury to his left hand that required him to learn how to play guitar again after five surgeries. The duo recorded their fifth album at a rented house in Los Angeles, as well as New York City's Electric Lady Studios, with Hince co-producing with John O'Mahony. Ash & Ice, one of the band's most somber sets of songs, arrived in June 2016. ~ Heather Phares