She was born in Georgia in 1974 and began singing in earnest at age four. As a teen she played in local bands. Her influences ranged from gospel and pop to classic rock and even grunge.

Nettles began her recording career as part of another duo, Soul Miner's Daughter with songwriter Cory Jones. The pair recorded two albums, 1996's The Sacred and Profane and 1998's Hallelujah. They received widespread critical notice and their albums sold respectably. They played some major festival dates, including 1999's Lilith Fair.

After the band broke up, Nettles created her own band and recorded three solo albums, 2000's Story of Your Bones and 2002's Gravity: Drag Me Down and Rewind. The Jennifer Nettles Band's recordings received major market airplay, and at the debut Independent Music Awards, she received the award for Independent Artist of the Year.

In 2003, she co-founded Sugarland with Bush and songwriter Kristen Hall; the latter left after the group's 2004 debut, Twice the Speed of Life. After five studio albums and one live recording with Sugarland, Nettles took a break from the band, had a child, and recorded a solo album entitled That Girl with producer Rick Rubin and an all-star cast. It was released in January of 2014, debuting at number one on Billboard's Country Albums chart and five on the Top 200. That Girl didn't produce any major hits -- the title track topped out at 37 -- and Nettles switched to Big Machine Records for 2016's Playing with Fire. ~ Thom Jurek