He lost his parents early in life through multiple tragedies; his mother died of pneumonia a week after his birth, and his father was lynched by the Klu Klux Klan when he was five.

Red began recording for Chess in 1949, then joined the Army. After his discharge, he played with John Lee Hooker in Detroit for almost two years in the late '50s, and continued through the '60s and '70s with recording sessions for Chess, Checker, Atlas, Glover, Roulette, L&R, and Tomato, among others.

Louisiana Red moved to Hanover, Germany in 1981, and maintained a busy recording and performing schedule through the subsequent decades into the new millennium, his 21st century releases including 2001's Driftin' on Earwig, 2002's A Different Shade of Red on Severn, 2004's Bad Case of the Blues on Mojo Tone, 2005's No Turn on Red on Hightone and Hot Sauce on Red Lightnin', and 2008's Back to the Black Bayou (recorded in Norway with producer/guitarist Little Victor) on Ruf. He died in Germany in 2012 when his thyroid imbalance brought on a stroke. ~ Ron Wynn