Guitar Wolf were formed in Nagasaki in 1987 when Seiji, a vocalist who picked up guitar after discovering the raunchy sound of Link Wray, crossed paths with Billy, a bassist who was working in a punk rock shop located next door to the '50s boutique where Seiji was employed. One of Seiji's co-workers, Narita, played drums, and the three decided to put together a band. They named their new trio Guitar Wolf, and inspired by the Ramones, they took on the stage names Guitar Wolf (Seiji), Bass Wolf (Billy), and Drum Wolf (Narita). Narita didn't last long in the band, and Toru took over as the new Drum Wolf.

In 1993, the band released its first album, Wolf Rock!, a lo-fi effort recorded in Seiji's basement. That same year, Guitar Wolf toured the United States for the first time; Eric Friedl of the Oblivians saw their performance at the Garageshock Festival in Memphis and was so knocked out he launched Goner Records to release Wolf Rock! in America. Their second album, Run Wolf Run, was released in Japan in 1994, followed by another trip to the United States. An in-store appearance at a record store in New York City was seen by a representative of the successful indie label Matador Records, who signed Guitar Wolf to a deal and released their next three albums, Missile Me! (1995), Planet of the Wolves (1997), and Jet Generation (1999). (Matador enthusiastically publicized the latter LP as the loudest album ever made.) The band was regularly staging international tours by this point, sharing stages with friends and fans like the Oblivians, the Cramps, and the Jon Spencer Blues Explosion.

In 2000, filmmaker Tetsuro Takeuchi made the film Wild Zero, which starred the three members of Guitar Wolf as themselves in a crazed comedy-drama in which they had to deal with zombies and alien interlopers. In the wake of Wild Zero's release, Guitar Wolf struck a new U.S. deal with the punk rock label Narnack Records; their first release for the label was Rock 'n' Roll Etiquette. Narnack would release the group's next three studio albums, as well as a "best-of" set, 2005's Golden Black.

The year 2005 marked the end of an era for Guitar Wolf when Billy, aka Bass Wolf, died of a heart attack at the age of 38. Though devastated by the news, Seiji and Toru decided to continue the band, and in September 2005 the group played its first concert with its new bassist, 19-year-old U.G. U.G. made his recording debut with Guitar Wolf on the 2007 album Dead Rock, and in 2009 the group launched its own Guitar Wolf label with the Jet Satisfaction EP. The group maintained its busy schedule of live work in Japan, Europe, and North America, and ducked back into the studio to cut 2011's Spacebattleshiplove. Beast Vibrator followed in 2013. After a few years of relative quiet, in 2016 Guitar Wolf were back with a new album, T-Rex from a Tiny Space Yojouhan, and they scheduled supporting tours of Japan and North America. ~ Mark Deming