Drummer Cameron Losch, guitarists Lee McKinney and Matt Pantelis, vocalist Ronnie Canizaro, keyboardist Joe Buras, and bassist David Da Rocha all met while in high school.

The band's signature blend of thrash and progressive, melodic death metal came to the attention of Sumerian Records; they signed the band (all of whose members were 18 at the time) and released The New Reign in 2007. Pantelis left in 2008 before the recording of 2009's A Higher Place. That album sold well enough to land inside the Top 100. All Shall Perish guitarist Jason Richardson temporarily joined the band in 2009. He played on 2011's The Discovery (an album that was cut using seven-string guitars) before being fired later in the year. Produced by the band, it didn't place as high in the Top 100, but fared better than all previous outings on various indie and metal charts.

Pared down to a quintet (their present lineup), Born of Osiris released Tomorrow We Die Alive in August of 2013. In another sonic shift, they opted for a more orchestrated sound, one that involved more vocal layers and programmed orchestration by co-producer Nick Sampson. Buras' keyboards were a central focus on the set, but the band's attack remained aggressive as ever. The album placed inside the Top 30 during its release week and inside the Top Ten on various other charts.

After aggressive touring, the band re-entered the studio. In the summer of 2015, Born of Osiris began leaking small bits and piece of a forthcoming, somewhat conceptual album. Its 12 tracks were divided into three "levels": The Binding, The Fight, and The Release, with four cuts in each. Titled Soul Sphere, it was released while Born of Osiris were in the middle of a lengthy tour. Just before the album's October 23 street date, guitarist McKinney broke his foot in several places. It temporarily forced the band off the road. ~ Thom Jurek